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Term of the Day

Natural History Study

A natural history study is a preplanned intended to track the course of the disease. Its purpose is to identify demographic, genetic, environmental, and other variables (e.g., treatment modalities, concomitant medications) that correlate with the disease’s development and outcomes. Natural history studies are likely to include patients receiving the current standard of care and/or emergent care, which may alter some manifestations of the disease.

L

Local Site Investigator

A local site investigator is a medical professional who is responsible for conducting a clinical trial at a specific site or location. The local site investigator is responsible for recruiting and enrolling participants in the trial, collecting and analyzing data, and ensuring that the trial is conducted in accordance with the study protocol and all applicable regulations and guidelines. In the context of central imaging in a clinical trial, the local site investigator may be responsible for collecting medical imaging data from participants and submitting it to the central review facility for analysis and interpretation.

See Investigator.